Micronutrient Status of COVID-19 Hospitalized Patients – A Systematic Review

Coronavirus Disease 2019 (Covid-19) pandemic has created a global health crisis. The present Systematic Review evaluated the impact of micronutrient status on the occurrence and prognosis of Covid-19. The review was done using PRISMA Statement. The main search engines used in the present research were PubMed, Google Scholar, ScienceDirect and Springer. The search explored all the relevant studies related to micronutrient status of hospitalized Covid-19 patients/critically ill Covid-19 patients, with or without co-morbidities. The micronutrients studied were Vitamins A, B, C, D and K and Minerals – Zinc and Selenium. All study designs such as, Retrospective, Cohort, Prospective and Case-Control were included papers published till February, 2021. A total of 6944 articles were identified from the databases (PubMed- 657; Google Scholar- 1504, ScienceDirect- 2840 and Springer- 194) and screened by four reviewers. A total of 42 were included for the review.

The present systematic review showed lower micronutrient levels among Covid19 patients. Hypovitaminosis mainly Vitamin D and lower levels of minerals pose a great jolt on the body’s immunity and other prognostic parameters such as mortality, longer hospital stay, ICU admissions, and higher CRP levels among Covid 19 patients.

Keywords: Covid-19, Hospitalized patients, Co-morbidities, Nutrition, Micronutrients, Immunity