Page 4 - Signals
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1. GLOBAL HEALTH ................................................. 1
A. Climate Change and Health .......................... 1 B. Global Burden of Health................................. 1 C. Canadian Health.............................................. 2
i. Aging in Canada .......................................... 2
ii. Food Insecurity in Canada ......................... 4 D. US Health.......................................................... 5
2. RESEARCH SIGNALS ........................................... 6
A. Adolescent Health: Approaches to Reduce Cardiovascular Risks and Weight...................6 i. Diet and Home Food Delivery ...................6 ii. Cardiovascular Health and Interrupting
Sedentary Behavior....................................6 B. Epigenetics and Health .................................7 i. Epigenetics and BMI ..................................7
ii. Epigenetic Changes and Aged-Related Macular Degeneration ...............................7 a. Diet, Exercise, Smoking, and
Genes and AMD ...................................7 b.  Lifestyle, Vitamin D De ciency, and 
Genes and AMD ...................................7 C. Circadian Rhythm Disruption:
Circadian Control of Glucose Metabolism.....8
3. DISCOVERY SIGNALS ......................................... 9
A. Reconstructing the Cerebral Cortex
With 3D Mapping..........................................9 B. Precision Medicine and Big Data...................9
i. NIH Announces Framework for Building National, Large-Scale Research Cohort,
a Key Component of the President’s Precision Medicine Initiative.......................9
C. Human Microbiome and Health:
Going Beyond the Gut ................................10 i. Fungal Diversity in Human Skin................10 ii. Oral Microbiome and Health...................11 iii. Gut–Eye Microbiome Connection..........11 iv. Gut–Brain Microbiome Connection:
A Paradigm Shift in Neuroscience ..........11 v. Gut–Immunology Microbiome
Connection: A Potential Cause
of Allergy Development?.........................12 vi. Developing a Footprint for
Microbiome Nutrition Research..............12 vii. Phase 2 of HMP .....................................13 viii. New Research Areas for Funding .........13
D. Cracking the Olfactory Code ......................14
4. INNOVATION AND TECHNOLOGY
FORECAST .......................................................... 15 A. Combinatorial Forecasts: A Glimpse Into
the Future Frontiers of Innovation...............15 B. Digital Technology Trends ........................... 15
5. CONSUMER TRENDS ........................................ 18
A. Canadian Trends.......................................... 18
B. US Consumer Trends ................................... 18
C. European Consumer Trends........................19 D. Global Trends .............................................. 19
6. REGULATORY SCIENCES, POLICY,
PRIORITY, AND MOVEMENT............................ 20
A. Regulatory Science Program at
FDA and NIH ............................................... 20
B. Antibiotic Monitoring .................................. 21 C. Added Sugars.............................................. 21 D. US and Canada Food and
Dietary Guidelines.......................................21 i. US Dietary Guidelines ............................. 21 ii. Canada’s Food Guide.............................22
E. US and Canada Federal Agency Priorities...22 i. USDA.......................................................22 a. USDA Agricultural Research Service ... 22
b. USDA National Institute of Food
and Agriculture................................... 22 ii. NIH (Nutrition)......................................... 22
iii. Centers for Disease Control
and Prevention ....................................... 23
iv. Health Canada........................................ 23 F.  Signi cant Reorganization ............................ 23
i.  Of ce of Nutrition Research Within 
the NIDDK................................................23
G. Innovation Versus Science: At What Point
Do They Part Company? ............................. 24 H.  Citizen Science Movement on the Rise ....... 25 I. The Bioethics of Animal Research...............25
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