ILSI shares science to diverse audiences by hosting, sponsoring, and co-organizing a variety of events around the world. These include independent symposia; workshops; hands-on scientific training; and sessions held as part of the program of larger scientific and professional meetings.

 

Upcoming Events

Workshop ‘The Use of AOPs in Safety Evaluation of Food Additives’

Brussels, Belgium

Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic representation of critical toxicological effects that propagate over different layers of biological organization from the initial interaction of a chemical with a molecular target to an adverse outcome at the individual or population level. Adverse outcome pathways are currently gaining momentum, especially in view of their many potential applications as pragmatic tools in the fields of toxicology, and risk and safety assessment. However, to date there has been little focus on food additives and how AOPs can be used as part of their risk and safety assessments.

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Technical Training Program: Safety Assessment of Foods and Feeds Derived from Genetically Engineered Plants (Phase I)

Beijing, China

Implemented by the ILSI Research Foundation, this technical training program is structured to provide Chinese public-sector scientists in-depth technical information about the purpose, design, and conduct of studies used to inform safety assessments of foods and feeds derived from genetically engineered (GE) crops.

Read more

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By Invitation Only. 

Implemented by the ILSI Research Foundation, this technical training program is structured to provide Chinese public-sector scientists in-depth technical information about the purpose, design, and conduct of studies used to inform safety assessments of foods and feeds derived from genetically engineered (GE) crops. The program is designed using a phased approach, with Phase I being a workshop aimed at establishing a baseline understanding of the concepts and principles of GE food and feed safety assessment. Topics will include the whole food safety assessment paradigm, as well as discussion of toxicity and allergenicity testing, compositional assessment, and animal testing.

Participants are asked to complete the eLearning module “Concepts in the Safety Assessment of Novel Food and Feed” in advance of the Phase I workshop.

Provisional Agenda

Day 1

Day 2

Day 3

Day 1

Introduction of Key Concepts and Regulatory Landscape

Welcome and Overview of the Workshop
Dr. Bhavneet Bajaj, ILSI Research Foundation, USA

Regulation of Genetically Engineered Foods and Livestock Feeds in China
TBD

International Guidance for Assessing Foods and Feeds Derived from Genetically Engineered Plants
Dr. Donald MacKenzie, Donald Danforth Plant Science Center, USA

Key Concepts in the Risk Assessment of Genetically Engineered Crops
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Question & Answer Session

Applying Problem Formulation to the Safety Assessment of Genetically Engineered Foods and Feeds
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Breakout Exercise 1

Accessing Information: Useful Resources for GE Food/Feed Safety Assessment
Dr. Bhavneet Bajaj, ILSI Research Foundation, USA

Breakout Exercise 2

Day 2

Delving into Food and Feed Safety Assessments (I)

Recap and Questions from Day 1
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Key Concepts in GE Food/Feed Assessment: Compositional Analyses
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Accessing Crop Compositional Data to Inform GE Food/Feed Safety Assessment
Dr. Bhavneet Bajaj, ILSI Research Foundation, USA

Breakout Exercise 3

Characterization of the Genetic Modification and the Novel Protein(s)
Dr. Donald MacKenzie, Donald Danforth Plant Science Center, USA

Breakout Exercise 4

Assessing Potential Toxicity
Dr. Jason Roper, DuPont Haskell Global Centers for Health and Environmental Sciences, USA

Breakout Exercise 5

Day 3

Delving into Food and Feed Safety Assessments (II)

Recap and Questions from Day 2
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Understanding Animal Feeding Studies in the Context of GE Food/Feed Safety Assessments
Dr. Jason Roper, DuPont Haskell Global Centers for Health and Environmental Sciences, USA

Plenary Group Discussion

Assessing Potential Allergenicity
Dr. Donald MacKenzie, Donald Danforth Plant Science Center, USA

Breakout Exercise 6

Explaining the Safety Assessment to Others
Dr. Donald MacKenzie, Donald Danforth Plant Science Center, USA

Feedback, Discussion, and Review

Preparing for the Phase II Workshop
Dr. Monica Garcia-Alonso, Estel Consult Ltd., UK

Presentation of Completion Certificates & Workshop Closure

Phase II

A five-day workshop is planned for June 2019, focusing on laboratory tours and demonstrations of how tests are managed and conducted, as well as how data are collected and interpreted. Phase II will include a review of the concepts from Phase I, with an additional focus on critical reading and review of study reports. Participants will be asked to complete the eLearning module “Application of Problem Formulation for Food and Feed Safety Assessment” in advance of the Phase II workshop.

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Most regulatory systems have developed standard test methods and data requirements for addressing the potential effects on non-target organisms (NTO) resulting from their exposure to genetically engineered plants expressing Bt proteins (insecticidal proteins primarily derived from Bacillus thuringiensis). However, recent developments in multiple technologies have led to the production of GE plants that incorporate pest protection without pesticidal proteins (e.g., using RNAi) or use of proteins that are not functionally related to Bt proteins. Although the overall assessment paradigm for GE plants is robust and can still be used to produce NTO assessments, there are ongoing discussions about the appropriate NTO tests and measurement endpoints for these new technologies. When is it appropriate to conduct sublethal endpoint assessment testing? What types of assays should be employed?

To answer such questions, the ILSI Research Foundation is convening scientists from academia, government, and industry to participate in a workshop on sublethal endpoints in NTO testing for non-Bt GE crops on March 5-6, 2019 in Washington, D.C. The criteria for making decisions regarding sublethal endpoint assessment testing that are developed during the workshop will be valuable in guiding future risk assessments of GE plants where sublethal effects on NTOs might be anticipated.

Provisional Agenda

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