ILSI entities around the world publish scientific research articles, literature reviews, gap analyses, and meeting proceedings in peer-reviewed journals and publications. Our research has a flawless track record. In fact, not one of the 1,000+ articles ILSI has published since our organization's founding has ever been retracted.
In addition, ILSI publishes books, monographs, white papers, and newsletters. Our commitment to the highest scientific standards and our adherence to rigorous scientific principles demonstrate ILSI's integrity in research.
Browse ILSI's research publications, including the latest findings and in-depth analyses that contribute to advancing knowledge in the nutrition, food safety, sustainability, and health fields. Whether you're a fellow researcher, a student, or simply curious, our scientific articles provide valuable insights into the work that drives innovation and discovery.
Below, our publications are listed by publication date, from the newest article to the oldest. You can also filter the list by title or publication type.
ILSI's Research Library:
Publication Date
Journal Articles
Maternal diet, nutritional status and infant birth weight in Malaysia: a scoping review
BMC Pregnancy and Childbirth, 2022
- ILSI Southeast Asia Region
Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research
Trends in Food Science & Technology, 2022
- ILSI Europe
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
Allergen quantitative risk assessment within food operations: Concepts towards development of practical guidance based on an ILSI Europe workshop
Food Control, 2022
- ILSI Europe
Commissioned by the Food Allergy Task Force.
The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
Archives of Toxicology, 2022
- ILSI Europe
Commissioned by the Food Contaminants Task Force.
Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults
Journal of Cachexia, Sarcopenia and Muscle, 2022
- ILSI Europe
Commissioned by the Heath Benefits Assessment of Foods Task Force.
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To access the journal article, please click here.
[post_title] => Maternal diet, nutritional status and infant birth weight in Malaysia: a scoping review [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => maternal-diet-nutritional-status-and-infant-birth-weight-in-malaysia-a-scoping-review [to_ping] => [pinged] => [post_modified] => 2022-06-27 22:08:03 [post_modified_gmt] => 2022-06-28 02:08:03 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.org/publication/maternal-diet-nutritional-status-and-infant-birth-weight-in-malaysia-a-scoping-review/ [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [1] => WP_Post Object ( [ID] => 32511 [post_author] => 24 [post_date] => 2022-05-31 04:54:54 [post_date_gmt] => 2022-05-31 08:54:54 [post_content] =>Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies
NEW APPROACHES FOR FOOD SAFETY
Background: Methods and approaches that can be used in food and nutrition research are changing at a faster pace than ever. Whereas animal methods are mostly known for their use in food safety analysis (see Part I), they also play in important role in proof-of-concept and mechanistic studies of products, as well as studying potency, efficacy, and tolerance of foods and food ingredients. Members of the International Life Sciences Institute (ILSI) Europe have formed an expert group to review possibilities, opportunities, and challenges for the potential use of alternative testing strategies in nutrition research and regulatory requirements, supporting the 3Rs principle of Replacement, Reduction, Refinement of animal research, which can ultimately be used in support of regulatory submissions for pre-market authorisation.
Scope and approach: For the different areas of food for specific groups and health claims, the acceptability of non-animal approaches is evaluated in comparison to legislative requirements in Europe. The alternative approaches considered cover emerging tools and methodologies such as organoids, organs-on-a-chip or human in vitro gastrointestinal simulators.
Conclusions: In nutrition research, there has been a long tradition of following a certain experimental trajectory for grounding scientific hypotheses starting from in vitro data moving on to in vivo verification in a preferred animal model and finally proving this in a human setting. From a regulatory perspective there is no specific requirement for animal experimentation that justifies the use of the majority of animal experiments in the
assessment of nutritional content and value of food products. However, animal data are mostly considered as the standard, and guidance for alternative approaches that would be accepted is lacking. It is therefore important to further build evidence and offer validation for the adequacy of already existing in vitro tools to ensure their suitability for substantiating dose levels and further planning clinical trials. What are we waiting for? Keywords ExpandNon-animal testing, Nutrition research, Regulation
To download this open-access article, please click here.
This work was commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
[post_title] => Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => animal-free-strategies-in-food-safety-nutrition-what-are-we-waiting-for-part-ii-nutrition-research [to_ping] => [pinged] => [post_modified] => 2023-04-13 10:52:34 [post_modified_gmt] => 2023-04-13 14:52:34 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.org/?post_type=publication&p=32511 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [2] => WP_Post Object ( [ID] => 31977 [post_author] => 24 [post_date] => 2022-04-13 11:14:07 [post_date_gmt] => 2022-04-13 16:14:07 [post_content] =>Food Allergy Task Force
NEW APPROACHES FOR FOOD SAFETY
Quantitative risk assessment (QRA) for allergens exists in many different forms with different requirements placed on the risk assessor depending on the question that needs to be answered. An electronic workshop held in October 2020 and comprising representatives from a wide range of food allergy and allergen stakeholder groups identified that a summary of current best in class guidance, identified gaps, potential improvements & harmonization of allergen QRA arising largely from cross contact would be very beneficial. The current manuscript provides an introduction to allergen QRA and an overview of inputs potentially needed for different QRA methods, when deemed feasible and necessary. It also introduces the European branch of the International Life Sciences Institute (ILSI Europe) Expert Group (EG), created to attempt to achieve consensus on the methodologies needed for allergen QRAs by food business operators, and their implementation. Areas of focus include proactive assessments for food production under normal conditions, both in the upstream supply chain and in food production facilities, and reactive assessments as part of an allergen incident response. As a follow-up report to the October 2020 electronic workshop, the current manuscript provides an overview of allergen QRA and insights into the guidance being developed. This manuscript will itself be followed by more detailed guidance for allergen QRA published open access as an ILSI Europe report.
Link to download the full-text
Keywords ExpandAllergens; Quantitative risk assessment (QRA); Supply chain; Incidents; Cross-contact; Precautionary allergen labelling (PAL)
[post_title] => Allergen quantitative risk assessment within food operations: Concepts towards development of practical guidance based on an ILSI Europe workshop [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => allergen-quantitative-risk-assessment-within-food-operations-concepts-towards-development-of-practical-guidance-based-on-an-ilsi-europe-workshop [to_ping] => [pinged] => [post_modified] => 2023-01-04 06:38:08 [post_modified_gmt] => 2023-01-04 11:38:08 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.org/?post_type=publication&p=31977 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [3] => WP_Post Object ( [ID] => 31801 [post_author] => 24 [post_date] => 2022-03-29 03:35:38 [post_date_gmt] => 2022-03-29 08:35:38 [post_content] =>The "totality" of the human exposure is conceived to encompass life-associated endogenous and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only formed in foods by heat processing, but also occur endogenously in the organism as physiological components of energy metabolism, potentially also generated by the human microbiome. To arrive at a comprehensive risk assessment, it is necessary to understand the contribution of in vivo background occurrence as compared to the ingestion from exogenous sources. Hence, this review provides an overview of the knowledge on the contribution of endogenous exposure to the overall exposure to putative genotoxic food contaminants, namely ethanol, acetaldehyde, formaldehyde, acrylamide, acrolein, α,β-unsaturated alkenals, glycation compounds, N-nitroso compounds, ethylene oxide, furans, 2- and 3-MCPD, and glycidyl esters. The evidence discussed herein allows to conclude that endogenous formation of some contaminants appears to contribute substantially to the exposome. This is of critical importance for risk assessment in the cases where endogenous exposure is suspected to outweigh the exogenous one (e.g. formaldehyde and acrolein).
Link to download the full-text
Keywords ExpandEndogenous exposure; Exposome; Genotoxins; Process-related contaminants
Commissioned by the Food Contaminants Task Force.
[post_title] => The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => the-role-of-endogenous-versus-exogenous-sources-in-the-exposome-of-putative-genotoxins-and-consequences-for-risk-assessment [to_ping] => [pinged] => [post_modified] => 2023-01-04 11:20:28 [post_modified_gmt] => 2023-01-04 16:20:28 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.org/?post_type=publication&p=31801 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) [4] => WP_Post Object ( [ID] => 31872 [post_author] => 24 [post_date] => 2022-04-07 15:28:06 [post_date_gmt] => 2022-04-07 15:28:06 [post_content] =>We performed a systematic review, meta-analysis, and meta-regression to determine if increasing daily protein ingestion contributes to gaining lean body mass (LBM), muscle strength, and physical/functional test performance in healthy subjects. A protocol for the present study was registered (PROSPERO, CRD42020159001), and a systematic search of Medline, Embase, CINAHL, and Web of Sciences databases was undertaken. Only randomized controlled trials (RCT) where participants increased their daily protein intake and were healthy and non-obese adults were included. Research questions focused on the main effects on the outcomes of interest and subgroup analysis, splitting the studies by participation in a resistance exercise (RE), age (<65 or ≥65 years old), and levels of daily protein ingestion. Three-level random-effects meta-analyses and meta-regressions were conducted on data from 74 RCT. Most of the selected studies tested the effects of additional protein ingestion during RE training. The evidence suggests that increasing daily protein ingestion may enhance gains in LBM in studies enrolling subjects in RE (SMD [standardized mean difference] = 0.22, 95% CI [95% confidence interval] 0.14:0.30, P < 0.01, 62 studies, moderate level of evidence). The effect on LBM was significant in subjects ≥65 years old ingesting 1.2-1.59 g of protein/kg/day and for younger subjects (<65 years old) ingesting ≥1.6 g of protein/kg/day submitted to RE. Lower-body strength gain was slightly higher by additional protein ingestion at ≥1.6 g of protein/kg/day during RE training (SMD = 0.40, 95% CI 0.09:0.35, P < 0.01, 19 studies, low level of evidence). Bench press strength is slightly increased by ingesting more protein in <65 years old subjects during RE training (SMD = 0.18, 95% CI 0.03:0.33, P = 0.01, 32 studies, low level of evidence). The effects of ingesting more protein are unclear when assessing handgrip strength and only marginal for performance in physical function tests. In conclusion, increasing daily protein ingestion results in small additional gains in LBM and lower body muscle strength gains in healthy adults enrolled in resistance exercise training. There is a slight effect on bench press strength and minimal effect performance in physical function tests. The effect on handgrip strength is unclear.
Download the full open-access article here
or click on the image below to download the one-pager summary.
Commissioned by the Health Benefits Assessment of Food Task Force
[post_title] => Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => systematic-review-and-meta-analysis-of-protein-intake-to-support-muscle-mass-and-function-in-healthy-adults [to_ping] => [pinged] => [post_modified] => 2023-01-27 10:48:19 [post_modified_gmt] => 2023-01-27 15:48:19 [post_content_filtered] => [post_parent] => 0 [guid] => https://ilsi.org/?post_type=publication&p=31872 [menu_order] => 0 [post_type] => publication [post_mime_type] => [comment_count] => 0 [filter] => raw ) ) [post_count] => 5 [current_post] => -1 [before_loop] => [in_the_loop] => [post] => WP_Post Object ( [ID] => 32759 [post_author] => 349 [post_date] => 2022-06-27 22:05:03 [post_date_gmt] => 2022-06-28 02:05:03 [post_content] =>Women's diet and nutritional status during pregnancy are important in influencing birth outcomes. We conducted a systematic scoping review of the best available evidence regarding the dietary intake of Malaysian pregnant women, and the associations of maternal diet, anthropometry, and nutrition-related co-morbidities with the infant's birth weight (IBW). The study objectives were to examine: (1) the adequacy of micronutrient intake among pregnant women; and (2) the association of maternal factors (anthropometry, diet, plasma glucose and blood pressure) during pregnancy with IBW.
To access the journal article, please click here.
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