Regulatory Toxicology and Pharmacology, 2024
Consumers may be exposed via foods to a diverse range of substances that could be considered as contaminants. However, it is not always straightforward to understand the definition of a ‘contaminant’. The present review evaluates how various categories of food-relevant substances are considered in terms of being ‘contaminants’.
Academic Journal of Gastroenterology & Hepatology, 2024
- ILSI Southeast Asia Region
This publication serves as a comprehensive report from the ILSI SEA Region Gut Microbiome Conference Series held on October 28–29, 2021. The conference focused on recent scientific advances in gut microbiome research. Renowned international and regional experts explored key topics, including the infant gut microbiome, the gut microbiome’s role in human health, its interactions with the immune system, metabolic health, and its influence on cognitive and mental health. Each theme emphasized the impact of diet on the gut microbiome, highlighting dietary strategies to address dysbiosis implicated in various disease states.
Food and Chemical Toxicology, 2024
The Cramer classification scheme has emerged as one of the most extensively-adopted predictive toxicology tools, owing in part to its employment for chemical categorisation within threshold of toxicological concern evaluation. The characteristics of several of its rules have contributed to inconsistencies with respect to degree of hazard attributed to common (particularly food-relevant) substances. This investigation examines these discrepancies, and their origins, raising awareness of such issues amongst users seeking to apply and/or adapt the rule-set.
Nutrients, 2024
- ILSI Southeast Asia Region
This study examined the demographic and socioeconomic determinants of IYCF practices, and their impacts on the DBM among 2039 Vietnamese children aged 6–23 months from the General Nutrition Survey 2020.
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Abstract
Consumers may be exposed via foods to a diverse range of substances that could be considered as contaminants. However, it is not always straightforward to understand the definition of a 'contaminant'. The present review evaluates how various categories of food-relevant substances are considered in terms of being 'contaminants'. To this end these categories of food borne constituents are evaluated against the various criteria encountered in the available definitions of a food contaminant, including unintentional presence, harmful, existence of regulatory limits, and stakeholder perception. The categories of chemicals considered include: phytotoxins, mycotoxins, (heavy) metals, persistent organic pollutants (POPs), processing aids, process related contaminants, food contact materials (FCMs), pesticides and veterinary drugs. The evaluation revealed that usage of the term appears complex, and may differ between stakeholders. A common proposed definition of the term 'contaminant' could be 'a substance considered to require control measures due to the unacceptability of its context within a food'. Use of a dimension of harm results in equivocal outcomes because risk depends on the level of exposure. As the term 'contaminant' has influence on risk management including public policy, the motivations for applying the term should be subject to more detailed analysis and understanding.
One-pager
Read the full paper
Commissioned by the Food Contaminants Task Force
[post_title] => The definition of chemical contaminants in food: Ambiguity and consequences
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This publication serves as a comprehensive report from the ILSI SEA Region Gut Microbiome Conference Series held on October 28-29, 2021. The conference focused on recent scientific advances in gut microbiome research. Renowned international and regional experts explored key topics, including the infant gut microbiome, the gut microbiome's role in human health, its interactions with the immune system, metabolic health, and its influence on cognitive and mental health. Each theme emphasized the impact of diet on the gut microbiome, highlighting dietary strategies to address dysbiosis implicated in various disease states.
View Full Publication Here
[post_title] => Role of the Gut Microbiome in Human Health: A Report of the ILSI South East Asia Region Gut Microbiome Conference Series
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Abstract
The Cramer classification scheme has emerged as one of the most extensively-adopted predictive toxicology tools, owing in part to its employment for chemical categorisation within threshold of toxicological concern evaluation. The characteristics of several of its rules have contributed to inconsistencies with respect to degree of hazard attributed to common (particularly food-relevant) substances. This investigation examines these discrepancies, and their origins, raising awareness of such issues amongst users seeking to apply and/or adapt the rule-set.
A dataset of over 3000 compounds was assembled, each with Cramer class assignments issued by up to four groups of industry and academic experts. These were complemented by corresponding outputs from in silico implementations of the scheme present within Toxtree and OECD QSAR Toolbox software, including a working of a "Revised Cramer Decision Tree". Consistency between judgments was assessed, revealing that although the extent of inter-expert agreement was very high (≥97%), general concordance between expert and in silico calls was more modest (∼70%). In particular, 22 chemical groupings were identified to serve as prominent sources of disagreement, the origins of which could be attributed either to differences in subjective interpretation, to software coding anomalies, or to reforms introduced by authors of the revised rules.
Commissioned by the Threshold of Toxicological Concern Task Force
Read the full article here
[post_title] => Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme
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[post_title] => A relação entre a alimentação e o ganho de massa muscular: mitos e dicas
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In collaboration with University of Leeds, UK, and National Institute of Nutrition (NIN), Vietnam
Optimal infant and young child feeding (IYCF) practices are crucial to addressing the double burden of malnutrition (DBM), encompassing undernutrition (including micronutrient deficiencies) and overnutrition. This study examined the demographic and socioeconomic determinants of IYCF practices, and their impacts on the DBM among 2039 Vietnamese children aged 6-23 months from the General Nutrition Survey 2020.
Click here to view the full publication.
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Abstract
Consumers may be exposed via foods to a diverse range of substances that could be considered as contaminants. However, it is not always straightforward to understand the definition of a 'contaminant'. The present review evaluates how various categories of food-relevant substances are considered in terms of being 'contaminants'. To this end these categories of food borne constituents are evaluated against the various criteria encountered in the available definitions of a food contaminant, including unintentional presence, harmful, existence of regulatory limits, and stakeholder perception. The categories of chemicals considered include: phytotoxins, mycotoxins, (heavy) metals, persistent organic pollutants (POPs), processing aids, process related contaminants, food contact materials (FCMs), pesticides and veterinary drugs. The evaluation revealed that usage of the term appears complex, and may differ between stakeholders. A common proposed definition of the term 'contaminant' could be 'a substance considered to require control measures due to the unacceptability of its context within a food'. Use of a dimension of harm results in equivocal outcomes because risk depends on the level of exposure. As the term 'contaminant' has influence on risk management including public policy, the motivations for applying the term should be subject to more detailed analysis and understanding.
One-pager
Read the full paper
Commissioned by the Food Contaminants Task Force
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