ILSI entities around the world publish scientific articles on original research, literature reviews and gap analyses, as well as meeting proceedings in peer-reviewed journals and publications. Not one of the 1,000+ articles that ILSI has published over the last 45 years has ever been retracted. ILSI also publishes books, monographs, white papers, other scientific reports, annual reports and newsletters.
ILSI's flawless scientific publication track record, its commitment to the highest scientific standards and its adherence to rigorous scientific principles demonstrate its scientific integrity.
ILSI's publications are listed below by publication date, from the newest article to the oldest. You can also filter the list by title or publication type.
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The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review
Nutrients, 2022
Commissioned by the Obesity and Diabetes Task Force
A Systematic Review of Physical Activity Intervention Programs in ASEAN Countries: Efficacy and Future Directions
International Journal of Environmental Research and Public Health, 2022
Maternal diet, nutritional status and infant birth weight in Malaysia: a scoping review
BMC Pregnancy and Childbirth, 2022
Dietary Probiotics, Prebiotics and the Gut Microbiota in Human Health
2022
Commissioned by the Prebiotics and Probiotics Task Forces.
Animal-free strategies in food safety & nutrition: What are we waiting for? Part II: Nutrition research
Trends in Food Science & Technology, 2022
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
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Commissioned by the Prebiotics and Probiotics Task Forces.
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NEW APPROACHES FOR FOOD SAFETY
Background: Methods and approaches that can be used in food and nutrition research are changing at a faster pace than ever. Whereas animal methods are mostly known for their use in food safety analysis (see Part I), they also play in important role in proof-of-concept and mechanistic studies of products, as well as studying potency, efficacy, and tolerance of foods and food ingredients. Members of the International Life Sciences Institute (ILSI) Europe have formed an expert group to review possibilities, opportunities, and challenges for the potential use of alternative testing strategies in nutrition research and regulatory requirements, supporting the 3Rs principle of Replacement, Reduction, Refinement of animal research, which can ultimately be used in support of regulatory submissions for pre-market authorisation.Scope and approach: For the different areas of food for specific groups and health claims, the acceptability of non-animal approaches is evaluated in comparison to legislative requirements in Europe. The alternative approaches considered cover emerging tools and methodologies such as organoids, organs-on-a-chip or human in vitro gastrointestinal simulators.
Conclusions: In nutrition research, there has been a long tradition of following a certain experimental trajectory for grounding scientific hypotheses starting from in vitro data moving on to in vivo verification in a preferred animal model and finally proving this in a human setting. From a regulatory perspective there is no specific requirement for animal experimentation that justifies the use of the majority of animal experiments in the
assessment of nutritional content and value of food products. However, animal data are mostly considered as the standard, and guidance for alternative approaches that would be accepted is lacking. It is therefore important to further build evidence and offer validation for the adequacy of already existing in vitro tools to ensure their suitability for substantiating dose levels and further planning clinical trials. What are we waiting for? Keywords Expand
Non-animal testing, Nutrition research, Regulation
To download this open-access article, please click here.
This work was commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force.
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Nutrition Security and Societal Aspects
Background: The gold-standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold-standard methodology. Methods: Three databases, PubMed, Scopus, and Cochrane were searched, intervention studies and randomised controlled trials reporting data on dietary intake, a gold standard of analysis of insulin sensitivity (either euglycaemic-hyperinsulinaemic clamp or intravenous glucose tolerance test and secretion (acute insulin response to glucose), as well as surrogate markers for insulin sensitivity (either fasting insulin, area under the curve oral glucose tolerance tests and HOMA-IR) and insulin secretion (disposition index), were selected. Results: We identified thirty-five studies that were eligible for inclusion. We found insufficient evidence to predict insulin sensitivity and secretion with surrogate markers when compared to gold standards in nutritional intervention studies. Conclusions: Future research is needed to investigate if surrogate measures of insulin sensitivity and secretion can be repeatable and reproducible in the same way as gold standards.
Keywords ExpandInsulin Sensitivity; Insulin Secretion; Gold Standard; Surrogate Markers; Dietary Intervention Studies
To download this open-access article, please click here.
This work was commissioned by the Obesity and Diabetes Task Force.
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